Health Highlight: Fri. 26, May.
Today’s Highlight(s): Chronic stress might be triggering digestive issues, according to new research.
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THE BRIEF
In a research study 1 conducted on mice, researchers found that chronic stress exacerbates gut inflammation by triggering a chain of events from the brain to the gut that involves the release of inflammatory chemicals. The findings suggest the importance of stress management in conjunction with medical treatments and point to potential new avenues for therapeutic interventions targeting the brain-gut connection. 2
Key Points
The research suggests that chemical cues originating in the brain travel to nerve cells in the gut, leading to the release of inflammatory substances.
These chemicals act on neurons and glial cells in the gut, which in turn trigger immune cells to release molecules that cause inflammation.
The research also sheds light on the path from the brain to the gut and the role of glucocorticoids, which are released by the adrenal glands in response to stress.
The findings may have implications beyond inflammatory bowel disease (IBD), as stress is believed to affect inflammatory diseases in other organs as well.
“The implications of the work could reach beyond IBD. Stress is also thought to heighten inflammatory diseases of the skin and lungs, possibly through similar signalling [sic] pathways.” 2
Keywords 🏷️: #IBD #Stress #GutBrain #InflammatoryDisease #NatureMagazineNOTES
“The enteric nervous system relays psychological stress to intestinal inflammation”
https://doi.org/10.1016/j.cell.2023.05.001
“Chronic stress can inflame the gut — now scientists know why”
https://www.nature.com/articles/d41586–023–01700-y